Depression, Anxiety and Stress Management

Introduction: In 1950’s the clinical introduction of the fi rst two specifi cally anti-depressant drugs: iproniazid, a monoamineoxidase inhibitor and imipramine, the first tricyclic antidepressant started. Since that time up till now, many antidepressants working on different neurotransmitters and receptors linked to depression were discovered and introduced in clinical practice but the main advantage of them over the old ones is their higher tolerability by patients. Combining psychotherapy with pharmacological treatment can improve the success rate of treatment but a considerable portion of patients stay resistant to this combined treatment. Even with using electro-convulsive therapy (ECT) in treating resistant depression, up to 20% of patients don't respond to it. Th is means that there is still something missed in treating patients with resistant depression and something more is needed to treat resistant depression more effectively.